"U.S. scientists will arrive at Baikal at the start of next week. They will descend on roughly August 20 and 21," he said.
U.S. experts were invited to explore Baikal by the organizers of the expedition.
The spokesman added that scientists from other countries would also dive to the Baikal lakebed.
The expedition is set to run for two years, during which time the scientists will conduct around 160 dives in various areas of the lake. Research will include gathering information on tectonic plates and a search for archeological artifacts.
Baikal is the world's oldest lake, having formed an estimated 25 million years ago. Scientists taking part in the expedition have stressed that research is not aimed at exploiting possible oil and gas reserves, but at protecting Baikal's unique ecosystem.
The lake has been the focus of major environmental scares in recent years, with a last-minute change to an oil pipeline route that was set to pass near Baikal's shores, and environmental regulators' claims against a pulp mill accused of pumping large volumes of toxic waste into the lake.
Baikal, a UNESCO World Heritage site, holds around 20% of the planet's freshwater.
