Discovery docked with the ISS on June 2 as part of a nine-day stay involving three spacewalks to install a newly-delivered Japanese space lab. The shuttle is expected to land back at Kennedy Space Center in Florida on June 14.
A Russian Mission Control official confirmed the information. "The shuttle undocked from the ISS in a normal mode at 15.42 Moscow time [11.42 GMT].
The STS-124 shuttle crew, which blasted off from Cape Canaveral May 31, is commanded by Mark Kelly, 44, with Ken Ham serving as pilot. Mission specialists include Karen Nyberg, Ronald Garan, Michael Fossum and Japanese Aerospace Exploration Agency (JAXA) astronaut Akihiko Hoshide.
The seventh crew member Greg Chamitoff replaced Garrett Reisman, who had been on the ISS for three months.
The shuttle delivered its heaviest payload to the world's sole orbiter, the Japanese Pressurized Module (JPM) which is the second unit of the massive Kibo laboratory complex. The first unit, an experimental logistics module, was delivered to the ISS in March.
The team also delivered parts to fix a malfunctioning Russian toilet on the station.
