Speaking at a ministerial session of the Organization of American States (OAS) in Panama City, Nicolas Maduro said "a new plan exists to destabilize the country, with the U.S. behind it."
U.S. Secretary of State Condoleezza Rice said Monday that the OAS Secretary General, Jose Miguel Insulza, should go to Venezuela to address the country's human rights record, following the closure of the opposition-aligned RCTV television station - a measure that has sparked mass protests in the capital Caracas.
She also suggested that Insulza deliver a detailed report on his findings over what she called President Hugo Chavez's "sharpest and most acute" attack on democracy since the leftist, anti-U.S. Venezuelan leader came to power in the late 1990s.
Maduro described Rice's statement as "an unacceptable intervention" in his country's domestic affairs.
RCTV went off the air on May 27 after Chavez refused to renew its license over its light entertainment programming, and replaced with a new state-owned channel, Tves, aimed at promoting socialist ideology.
The 35-nation OAS' declared goals include strengthening democracy and promoting human rights across the Western Hemisphere.