Karadzic, who has dismissed the charges, plans to defend himself at trial.
The Srebrenica massacre, where up to 8,000 Bosnian Muslims were killed by Serb forces in 1995, is one of two main charges facing the wartime leader.
Earlier reports said Karadzic would aim to prove at the Hague tribunal that no genocide took place in Srebrenica, and that fatality figures were deliberately exaggerated.
If Karadzic declines to plead, the Hague-based court will file not-guilty pleas for him. If he pleads guilty, there will be no trial.
Karadzic, 63, was arrested in late July in Belgrade after more than a decade on the run.
During his first appearance before the International Criminal Tribunal for the Former Yugoslavia in late July, Karadzic cited a deal with former U.S. envoy to the Balkans Richard Holbrooke that he said guaranteed him immunity from prosecution if he disappeared from public life. Holbrooke has denied the deal.
Karadzic also said he will not get a fair trial and complained of "a media witch-hunt" against him.
